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Synthetic Bone Grafts

Detailed Technology Description

Bioengineers from UC San Diego have developed a hydrogel-based mineralization process to synthesize porous mineralized bone mimetic material. By varying pendant side-chain lengths to control matrix hydrophobicity, the inventors developed a means to regulate the nucleation of aptatite-like phases on a polymeric substrate.This technology can be used to develop mineral-polymer composite materials for use as scaffolds in bone tissue engineering and as bone grafts, as well as in other applications requiring the templated synthesis of organic/inorganic composite materials.

Supplementary Information

Patent Number: US8709452B2
Application Number: US13549045A
Inventor: Varghese, Shyni | Phadke, Ameya
Priority Date: 15 Jul 2011
Priority Number: US8709452B2
Application Date: 13 Jul 2012
Publication Date: 29 Apr 2014
IPC Current: A61K000900 | A01N006300 | A61K004700 | A61K004732
US Class: 424400 | 4240937 | 5147724 | 5147726 | 514781 | 514788
Assignee Applicant: The Regents of the University of California
Title: Synthetic bone grafts
Usefulness: Synthetic bone grafts
Summary: The composition is useful for treating a bone disease or disorder and for growing bone tissue (all claimed). No biological data given.
Novelty: Composition, useful for treating a bone disease or disorder and for growing bone tissue, comprises a hydrogel modified with amino acids having an anionic pendant side chain

Industry

Biomedical

Sub Category

Rehabilitation

Application No.

8709452

Others

State Of Development

Results from biocompatibility experiments suggests that the material is highly promising as a bone graft. A patent application has been filed. Additional detailed information is available under a secrecy agreement.

Related Materials

Phadke A, Zhang C, Hwang Y, Vecchio K, Varghese S. Templated mineralization of synthetic hydrogels for bone-like composite materials: role of matrix hydrophobicity. Biomacromolecules. 2010 Aug 9;11(8):2060-8.

Tech ID/UC Case

22465/2011-007-0

Related Cases

2011-007-0

*Abstract

Bone-mimetic mineral-polymer composite materials have several applications ranging from artificial bone grafts to scaffolds for bone tissue engineering. Current bone graft materials include ceramic powders, combinations of proteins and minerals, autologous bone grafts, allografts and xenografts. The greatest limitation with autografts is donor site morbidity while ceramic powders fail to provide structural support while poorly mimicking the composite structure of bone.

*IP Issue Date

Apr 29, 2014

*Principal Investigator

Name: Ameya Phadke

Department:

Name: Shyni Varghese

Department:

Country/Region

USA