Optical Space-Time Coding Technique in Microfluidic Devices
The invention delivers record performance with significant cost saving and simplified operation to favor point-of-care applications.
Disclosed are optical coding methods and devices to detect FS and LAS signals in a microfluidic channel using commodity Si PIN photoreceivers instead of sophisticated PMTs. In the invention, a spatial pattern on a mask is converted into a temporal waveform for both FS and LAS signals, thus enhancing the detection sensitivity utilizing digital signal processing algorithms as well as enabling measurement of the position (x, y) and velocity of each particle. The velocity and position information facilitate measuring particle behaviors in microfluidic devices and complex properties such as inertial focusing and fluid dynamic sample separation. The invention’s optical space-time coding has enabled achieving LAS coefficients of variations that are among the best for microfluidic devices. The viability of the technique has also been verified with lymphocyte samples, showing signal patterns comparable with commercial systems.
Inventor: Luo, Ren-Hong | Wei, Cheng-Ta
Priority Number: US7564281B2
IPC Current: H03L000706
US Class: 327156 | 327147 | 327163 | 375376
Assignee Applicant: Faraday Technology Corporation,Hsinchu
Title: Wide-locking range phase locked loop circuit using adaptive post division technique
Usefulness: Wide-locking range phase locked loop circuit using adaptive post division technique
Novelty: Wide-locking range phase locked loop circuit for application specific integrated circuit, has decision unit selecting divisor if phase difference signal indicates unlocked state and control voltage is not within range
Electronics
Circuit Design
9074978
Intellectual Property Info This technology has a patent pending and is available for licensing and/or sponsorship. Related Materials An Optical-Coding Method to Measure Particle Distribution in Microfluidic Devices, AIP Advances 1, 022155 (2011). Tech ID/UC Case 21898/2012-002-0 Related Cases 2012-002-0
Applying an Optical Space-Time Coding Method to Enhance Light Scattering Signals in Microfluidic Devices, Biomicrofluidics 5, 034116 (2011).
USA
