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High Resolution, Diagnostic Imaging of Fat Composition and Regional Location

Technology Benefits
Totally automated image reconstruction and data analysis.Requires only one breath-hold scan added to a standard MR examination.Yields diagnostic information that cannot be derived from other non-invasive means.
Technology Application
This technology can improve diagnostic utility for patients of diverse diseases that are characterized by specific types and locations of fat deposits. Such diseases include cancer, diabetes, and liver disease.
Detailed Technology Description
Commonly employed MRI techniques for separating water and fat exploit differences in the precession frequency of protons in fat and water. UC researchers have simplified and improved analysis and data processing by identifying three most-relevant parameters that can be used to qualitatively and quantitatively image fat. By reducing the complexity of an MRI-generated fat spectrum, one is able to significantly improve the diagnostic utility of a scan with minimal effect on the scan time.
Supplementary Information
Patent Number: WO2012061839A3
Application Number: WO2011US59660A
Inventor: BYDDER, Mark | HAMILTON, Gavin | MIDDLETON, Michael | SIRLIN, Claude
Priority Date: 5 Nov 2010
Priority Number: WO2012061839A3
Application Date: 7 Nov 2011
Publication Date: 2 Aug 2012
IPC Current: A61B0005055 | G06F001900
Assignee Applicant: The Regents of the University of California
Title: MRI-BASED FAT DOUBLE BOND MAPPING | MAPPAGE DE LIAISONS DOUBLES DE GRAISSE BASÉ SUR L'IMAGERIE PAR RÉSONANCE MAGNÉTIQUE
Usefulness: MRI-BASED FAT DOUBLE BOND MAPPING | MAPPAGE DE LIAISONS DOUBLES DE GRAISSE BASÉ SUR L'IMAGERIE PAR RÉSONANCE MAGNÉTIQUE
Summary: MRI method for producing fat characterization profile from acquired MRI image used in diagnosis and treatment plans for disease such as cancer to evaluate tumors/lesions and decide if malignant or benign, liver disease to differential between simple steatosis and steaohepatities, and diabetes to detect brown fat that is indicator for predisposition to develop diabetes.
Novelty: MRI method for producing fat characterization profile from acquired MRI image to determine type and saturation level of fat involves determining fat characterization parameters based on acquired magnetic resonance data
Industry
Biomedical
Sub Category
Medical Imaging
Application No.
9759794
Others

State Of Development

In vitro validation is complete. Studies with human subjects are underway: the type and quantity of fat in the abdomen are measured with 5 mm resolution in a 24 second scan.


Intellectual Property Info

Pending patents available under confidentiality; worldwide, non-exclusive IP rights and copyright (software) available.


Related Materials


Tech ID/UC Case

21265/2011-012-0


Related Cases

2011-012-0, 2008-830-1, 2010-814-1
*Abstract
Several study have suggested that fat composition and site of deposition can indicate the risk of many disorders, including cancer, type 2 diabetes, heart disease, and liver disease (NASH). In addition, regional differences in fat composition throughout the body suggest a depot-specific impact of stored fatty acids on adipocyte function and metabolism. Current diagnostic tools include MR spectroscopy, which has high spectral resolution but poor spatial resolution, and MRI IDEAL (iterative decomposition of water and fat with echo asymmetry and least squares estimation) gradient echo imaging, which can measure the amount but not the type of fat.
*IP Issue Date
Sep 12, 2017
*Principal Investigator

Name: Mark Bydder

Department:


Name: Gavin Hamilton

Department:


Name: Michael Middleton

Department:


Name: Claude Sirlin

Department:

Country/Region
USA

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