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Chemically Amplified Response Strategies for Medical Sciences

Technology Benefits

Potential advantages from molecularly engineering linear dual-response mechanisms into the backbone of polymeric nanoparticles include enhanced stability and prolonged shelf life, while also increasing the response sensitivity and efficacy of targeted delivery to diseased environments. In addition, this polymeric nano-carrier technology may reduce overall toxicity by decomposing into easily excretable fragments. This technology is designed to be versatile where the triggering group can be sensitive to a number of wavelengths.

Detailed Technology Description

Researchers from UC San Diego have designed a new light-sensitive degradable polymer containing a quinone-methide, self-immolative moiety, which can be triggered to degrade through multiple light-sensitive groups. Nanoparticles formulated from this polymer are capable of releasing their molecule payload upon irradiation by UV and NIR light. The details of this technology are published in the patent application (2011/038117).

Supplementary Information

Patent Number: US20120259267A1
Application Number: US13496486A
Inventor: Almutairi, Adah | Fomina, Nadezda | Sankaranarayanan, Jagadis
Priority Date: 23 Sep 2009
Priority Number: US20120259267A1
Application Date: 28 Jun 2012
Publication Date: 11 Oct 2012
IPC Current: C07C0049175 | A61K0039395 | A61K005100 | A61M003700 | B01J001908 | C07D031102 | C08F002056
US Class: 604020 | 2504921 | 42400111 | 4241301 | 525284 | 549283 | 568414
Assignee Applicant: The Regents of the University of California
Title: Chemically Amplified Response Strategies for Medical Sciences
Usefulness: Chemically Amplified Response Strategies for Medical Sciences
Summary: For delivering Payload to tissue, where the Payload comprises pharmaceutical agent, stem cell differentiation agents, immunogens, and antibodies (claimed); for amplifying sensitivity to electromagnetic radiation, or light, such as UV light or near infrared light.
Novelty: Composition for delivering Payload such as pharmaceutical agent, stem cell differentiation agents, immunogens and antibodies, to tissue comprises multi-photon responsive element covalently linked to self-immolative backbone subunit

Industry

Biomedical

Sub Category

Medical Composition

Application No.

8828383

Others

Intellectual Property Info

International patent application, published 31Mar2011 (2011/038117).

Related Cases

2012-355

Related Materials

Fomina N, McFearin C, Sermsakdi M, Edigin O, Almutairi A. UV and Near-IR Triggered Release from Polymeric Nanoparticles. J Am Chem Soc. 2010 Jul 21;132(28):9540-2.

Tech ID/UC Case

19815/2010-089-0

Related Cases

2010-089-0

*Abstract

With the rapid progress of nanotechnology over the past decade, there is growing interest in polymeric biomaterials that can be remotely disassembled in a controlled fashion upon an external stimulus but otherwise stable under physiological conditions. Various internal and external stimuli, such as pH, specific enzymes, temperature, and ultrasound, are being explored. Optical stimulus is especially attractive as it can be remotely applied for a short period of time with high spatial and temporal precision. Near-infrared (NIR) light can penetrate deeper into tissue and has many in vivo applications. Despite these advantages, there is a dearth of biomaterials that can efficiently respond to light, especially NIR light.

*IP Issue Date

Sep 9, 2014

*Principal Investigator

Name: Adah Almutairi

Department:

Name: Nadezda Fomina

Department:

Name: Jagadis Sankaranarayanan

Department:

Country/Region

USA