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Monoclonal Antibody Against mtPAP (Clone 3D2)

Technology Benefits: Specific antibody to detect mtPAP (clone 3D2) by antibody-antigen complex formation.

Technology Application: Immunocytochemistry/immunofluorescence (1:100-1:1000)* Immunoprecipitation Western blot (1:500-1:3000)* * Suggested dilutions

Detailed Technology Description: mtPAP creates the 3’ poly(A) tail of mitochondrial transcripts. The polymerase may use all four nucleotides but has higher activity with ATP and UTP in vitro. mtPAP plays a role in replication-dependent histone mRNA degradation and may also be involved in terminal uridylation of mature histone mRNAs prior to degradation. mtPAP may also be responsible for creating some UAA stop codons not encoded in mtDNA. The described mouse monoclonal IgG2b antibody binds to human mtPAP and has been described for use in immunocytochemistry/immunofluorescnece, immunoprecipitation, and western blot.

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Additional Technologies by these Inventors

Tech ID/UC Case

25122/2011-381-0

Related Cases

2011-381-0, 2011-086-0, 2011-375-0, 2011-376-0, 2011-377-0, 2011-378-0, 2011-379-0, 2011-380-0, 2011-382-0, 2011-383-0, 2011-384-0, 2011-385-0, 2011-386-0, 2011-387-0

*Abstract: Mouse monoclonal antibody against the human Poly (A) RNA polymerase, mitochondrial (mtPAP). This antibody has been tested for use in immunocytochemistry/immunofluorescence, immunoprecipitation, and western blot. .

*Principal Investigator: Name: Yoon Kim
Department:

Name: Eva Y H P Lee
Department:

Name: Wen Hwa Lee
Department:

Name: Dennis Wang
Department:

Country/Region: USA

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