Real-time, Single Step Bioassay With Ultra-high Sensitivity
- Technology Benefits
- Fast detection and diagnosis of complex diseasesFaster patient recovery Less testing via multiplexed measurements
- Technology Application
- Early stage cancer detectionBioassayForensic investigation -seminal droplets
- Detailed Technology Description
- None
- Supplementary Information
- Patent Number: US20110058164A1
Application Number: US2010772118A
Inventor: Zhang, Xiang | Ellman, Jonathan A. | Chen, Fanqing Frank | Sun, Cheng | Su, Kai-Hang | Wei, Qi-Huo
Priority Date: 2 Nov 2007
Priority Number: US20110058164A1
Application Date: 30 Apr 2010
Publication Date: 10 Mar 2011
IPC Current: G01J000344
US Class: 356301
Assignee Applicant: The Regents of the University of California
Title: Time resolved single-step protease activity quantification using nanoplasmonic resonator (NPR) sensor
Usefulness: Time resolved single-step protease activity quantification using nanoplasmonic resonator (NPR) sensor
Summary: As nanoplasmonic resonator (NPR) in nanoplasmonic resonance surface enhanced Raman scattering detection platform; for in vitro detection and measurement of enzymatic activity using a nanosensor; for real-time reaction monitoring of enzyme activity; for detecting the activity of multiple enzymes simultaneously (claimed); for enzymatic activity measurement used in drug screening, diagnosis and disease staging and molecular profiling; and also for detection of protease activity such as prostate specific antigen (PSA) and proteolytically active prostate specific antigen for diagnostic application in prostate cancer.
Novelty: Nanoplasmonic resonator used e.g. for in vitro detection and measurement of enzymatic activity comprises metallic nanodisks with alternating shielding layers having tagged biomolecule conjugated or tethered to the surface of the resonator
- Industry
- Disease Diagnostic/Treatment
- Sub Category
- Cancer/Tumor
- Application No.
- 8685743
- Others
-
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Tech ID/UC Case
17690/2006-121-0
Related Cases
2006-121-0
- *Abstract
-
Unfortunately, conventional methods for early stage cancer detection present high levels of background noise and involve time-consuming washing processes and often involve painful biopsy procedures. As a result, the acquisition of meaningful test results can require days of trials, simultaneously increasing a patient's recovery time and medical costs.
The present-day remedy for faster detection and diagnosis has been more lab technicians, more lab equipment, and, consequently, more money.
Fortunately, researchers at the University of California have developed a new technology that may present a cheaper and faster alternative to this remedy. Using an array of novel resonators to functionalize molecular indicators, researchers have been able to reduce the detection volume to nanometers in thickness, effectively reducing the background noise, eliminating the time consuming washing process, and increasing the Raman signal by more than 10 orders of magnitude. The increase in sensitivity makes it possible to sense the biomarkers secreted from single cancer cells.
- *IP Issue Date
- Apr 1, 2014
- *Principal Investigator
-
Name: Kai-Hang Su
Department:
Name: Cheng Sun
Department:
Name: Qi-Huo Wei
Department:
Name: Xiang Zhang
Department:
Name: Fanqing Frank Chen
Department:
Name: Jonathan Ellman
Department:
- Country/Region
- USA
