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POROUS/HOLLOW SHELLS FROM AQUEOUS DISSOLUTION OF BORATE GLASS

IP Title

METHOD FOR PREPARING POROUS SHELLS OR GELS FROM GLASS PARTICLES

Detailed Technology Description

None

Supplementary Information

Patent Number: US6358531B1
Application Number: US1999241492A
Inventor: Day, Delbert E. | Conzone, Samuel D.
Priority Date: 1 Feb 1999
Priority Number: US6358531B1
Application Date: 1 Feb 1999
Publication Date: 19 Mar 2002
IPC Current: A61K000916 | A61K000950 | C03C000100 | C03C001100 | C03C001200
US Class: 424489 | 0650213 | 424456 | 424464 | 424469 | 424478 | 502262 | 544129 | 977775 | 977906
Assignee Applicant: The Curators of the University of Missourilumbia
Title: Method for preparing porous shells or gels from glass particles
Usefulness: Method for preparing porous shells or gels from glass particles
Summary: The shells or porous gels may be filled with a liquid, gas or solid material, e.g. a chemotherapeutic drug (claimed). They can also be heat treated and used (i) as a filler in paints, resins, polymers or metals, (ii) as a bone growth or repair agent when administered to mammals, (iii) as a filter, (iv) as a precursor for nano sized powders, (v) as a thin surface film, (vi) to remove hazardous species such as chromates, arsenates and uranates from solution, or (vi) as a catalyst support medium (claimed).
Novelty: Preparation of shells or porous gels from glass particles, useful for forming carriers for chemotherapeutic drugs, as fillers, as bone growth or repair agents, for removal of hazardous agents or as catalyst support

Industry

Biomedical

Sub Category

Bioengineering

Application Date

Feb 1, 1999

Application No.

6,358,531

Others

*Abstract

Abstract of US Patent 6,358,531 - Method for preparing porous shells or gels from glass particles: A method is provided for preparing shells, concentric shells or porous, homogenous gels from alkali borate glass particles at low temperatures (i.e. room temperature or less than above 100.degree. C.). The alkali borate glass particles contain one or more cations such as aluminum which react with an aqueous solution containing an anion such as hydroxide to form an aqueous insoluble material having a solubility limit of less than about 0.01 wt. percent. The resulting shells or gels may be used in many different applications such as a filler in resins, as filters, precursors for nano-sized powders, as thin surface films or catalyst support media. The resulting shells or gels may also have a chemotherapeutic drug added thereto, following which the resulting product is administered to a mammal and the insoluble material is dissolved form the product in vivo through administration of chelating agent. Non-Confidential Abstract of Invention: A method for producing hollow/porous shells from glass particles at or near room temperature has been developed. This method uses a glass of an appropriate composition, which is crushed and made into spheres of the desired size. These spheres are then immersed in an aqueous solution at or near room temperature. While immersed, the glass spheres react with the solution and corrode non-uniformly. Complete non-uniform corrosion converts the solid glass spheres into porous/hollow shells. These porous/hollow shells are the same size and shape as the “as-made” microspheres, but they can contain up to 90% porosity. The primary advantages of this technique are that: porous/hollow shells of varying size can quickly and easily be produced at low temperatures; many compositions can be prepared simply by adding different insoluble cations to the “as-made” glass; the porosity can be varied over wide limits; and the porous/hollow shells can be easily filled with various liquids or gases at room temperature. These hollow/porous shells could be used in many applications, such as fillers in light weight polymer matrix materials, fillers in paints, drug delivery systems and catalyst supports.

*IP Issue Date

Mar 19, 2002

*Principal Investigator

Name: Delbert Day, Curators' Professor Emeritus

Department:

Name: SAMUEL CONZONE

Department:

Country/Region

USA