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Escherichia Coli Capable of Producing Isobutyraldehyde

Technology Benefits

Improved production of Isobutyraldehyde Industrial scale production Greatly reduced side product formation Potentially useful for production of other aldehydes

Technology Application

Renewable production of isobutyraldehyde

Detailed Technology Description

E. coli has long been used for the industrial production of valuable chemicals due to its fast growth rate, well-developed fermentation technology, and tools for genetic modification. In recent year, E. coli has seen great success in the production of many alcohols. However, there has been little effort to optimize E. coli for aldehyde production. Researchers at the University of California, Davis have developed a novel strain of E. coli capable of producing isobutyraldehyde in high titers without conversion to isobutanol. Aldehydes are reactive compounds useful for chemical feedstocks to generate many additional, more complex molecules. In particular, isobutyraldehyde can be later converted to isobutanol and isobutyrate, or be used to generate polymers.

Supplementary Information

Inventor: TARALP, Alpay
Priority Number: WO2011132020A1
IPC Current: C07F000718
Assignee Applicant: Sabanci Üniversitesi,TR
Title: PREPARATION OF SUBSTANTIALLY QUATERNIZED AMMONIUM ORGANOSILANE COMPOSITION AND SELF-STABILIZING AQUEOUS SOLUTION THEREOF | ÉLABORATION D'UNE COMPOSITION D'ORGANOSILANE À AMMONIUM SUBSTANTIELLEMENT QUATERNARISÉ ET SOLUTION AQUEUSE AUTO-STABILISANTE L'INCLU
Usefulness: PREPARATION OF SUBSTANTIALLY QUATERNIZED AMMONIUM ORGANOSILANE COMPOSITION AND SELF-STABILIZING AQUEOUS SOLUTION THEREOF | ÉLABORATION D'UNE COMPOSITION D'ORGANOSILANE À AMMONIUM SUBSTANTIELLEMENT QUATERNARISÉ ET SOLUTION AQUEUSE AUTO-STABILISANTE L'INCLUANT
Summary: The method is useful for synthesizing an organosilyl quaternary amine product (claimed).
Novelty: Synthesizing an organosilyl quaternary amine product, comprises preparing a two-component composition comprising precursor materials, where the process is terminated at a product conversion corresponding to a desired yield

Industry

Chemical/Material

Sub Category

Chemical/Material Application

Application No.

9701948

Others

Published Patent Application

Escherichia coli engineered for isobutyraldehyde production. WO 2013192237 A1

Related Materials

Isobutyraldehyde production from Escherichia coli by removing aldehyde reductase activity
Isobutyraldehyde production from Escherichia coli by removing aldehyde reductase activity. Gabriel M Rodriguez and Shota Atsumi.

Tech ID/UC Case

21866/2011-677-0

Related Cases

2011-677-0

*Abstract

Researchers at the University of California, Davis have developed strains of Escherichia coli capable of producing the valuable chemical feedstock, isobutyraldehyde. This strain is specifically optimized for the production of isobutyraldehyde.

*IP Issue Date

Jul 11, 2017

*Principal Investigator

Name: Shota Atsumi

Department:

Name: Gabriel Rodriguez

Department:

Country/Region

USA