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Method for Regulating Apoptosis

Technology Benefits

High degree of conservation among fission and fusion proteins Alternative target for therapeutic attenuation of apoptosis Target dynamins and thus prevents cells from dying

Technology Application

Treat conditions associated with apoptosis Mycocardial infarction, cancer, Parkinson's disease, amyotrophic lateral sclerosis (ALS), and and neurodegenerative diseases

Detailed Technology Description

A method for inhibiting cellular apoptosis through the regulation of mitochondrial fission and fusion has been identified by researchers at the University of California, Davis. The method for identifying small molecule inhibitors of mitochondrial fission fusion is described. Such compounds can be capable of regulating cellular apoptosis via their effects on mitochondrial membrane dynamics. UC Davis investigators have verified compound activities in both yeast and mammalian cell systems. Studies have indicated that one compound acts through the mediation of the mitochondrial fission dynamin related GTPase. In addition, UC Davis researchers have discovered that a small molecule inhibitor of Drp1, the mitochondrial division dynamin, blocks the mitochondrial outer membrane permeabilization in isolated mitochondria, the first step in apoptosis induced by truncated Bid (tBid). The new compound is termed mdivi-1.

Supplementary Information

Patent Number: US8450333B2
Application Number: US200828536A
Inventor: Nunnari, Jodi | Cassidy-Stone, Ann | Kurth, Mark
Priority Date: 9 Jun 2003
Priority Number: US8450333B2
Application Date: 8 Feb 2008
Publication Date: 28 May 2013
IPC Current: A01N004354 | A61K0031517 | C07D023972 | C07D023995 | C07D027736 | C07D027738 | C07D040914 | C07D049804 | C07D051304
US Class: 51426631 | 544285
Assignee Applicant: The Regents of the University of California
Title: Molecules for regulating cell death
Usefulness: Molecules for regulating cell death
Summary: For preparing composition useful for modulating mitochondrial fission in a cell; inhibiting or decreasing apoptosis in a cell and treating condition associated with apoptosis, e.g. Parkinson's disease, amyotrophic lateral sclerosis (ALS), stroke, heart attack, congestive heart failure, transplantation, alcoholic hepatitis, and drug-induced liver toxicity (claimed); decreasing cell or tissue damage; inhibiting mitochondrial fusion used to treat conditions associated with increasing apoptosis, e.g. neoplasia, cancer, and tumor; and also used to identify other molecules that modulate apoptosis by competition assays.
Novelty: New substituted mercaptoquinazolin-4(3H)-one compound useful as mitochondrial dynamin-related guanosine triphosphatase (GTPase) inhibitor for treating condition associated with apoptosis e.g. Parkinson's disease, stroke, heart attack

Industry

Agriculture

Sub Category

Plant

Application No.

8450333

Others

Related Materials

Cassidy-Stone A, Chipuk JE, Ingerman E, Song C, Yoo C, Kuwana T, Kurth MJ, Shaw JT, Hinshaw JE, Green DR, and Nunnari J. 2008. Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Dev Cell. 14(2):193-204.

Related Technologies

• Ligands for Alpha-4-Beta-1 Integrin

Tech ID/UC Case

11335/2003-504-0

Related Cases

2003-504-0

*Abstract

Method for inhibiting cellular apoptosis through the regluation of mitochondrial fission.

*IP Issue Date

May 28, 2013

*Principal Investigator

Name: Ann Cassidy-Stone

Department:

Name: Mark Kurth

Department:

Name: Jodi Nunnari

Department:

Country/Region

USA