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Bio-Olefins: Polymers with Biocompatible and/or Bioactive Capabilities

IP Title

Methods Of Making Functionalized Polymers

Detailed Technology Description

None

Supplementary Information

Inventor: Kohler, Anja S. | Mooradian, Daniel L. | Furcht, Leo T.
Priority Number: US5711959A
IPC Current: A61L003300
US Class: 424423 | 514822 | 523112 | 523113
Assignee Applicant: Regents of the University of Minnesotanneapolis
Title: Biocompatible materials
Usefulness: Biocompatible materials
Summary: USE The PL conjugated material is of use for a wide variety of medical and surgical devices and equipment. Examples in surgery are implants (e.g. for breast or ear), prostheses, vascular grafts, stents, stomach ports, heart valves, or any artificial part or device which replaces or augments a part of a living body or comes into contact with bodily fluids, esp. blood. Medical device examples are catheters, e.g., drain or angioplasty balloon, sutures, tubing, as in extracorporeal circuitry, membranes, as for haemodialysis or biosensors, needles, guide wires, blood pumps or filters, or diagnostic devices. A wide variety of materials, provided that the surface is modified to react with the PL, can be treated by the method; these include stainless steel, glass or other inorganics, and organic polymers, esp. polypropylene and polytetrafluoroethylene.
Novelty: Biocompatible materials linked to phospholipid moieties provides improved non-thrombogenic surface, used for implants, prostheses, vascular grafts, and medicinal and surgical devices

Industry

Biomedical

Sub Category

Rehabilitation

Application Date

Dec 9, 2002

Application No.

7,172,755

Others

*Abstract

Invention

The University of Florida is seeking a company interested in commercializing a method of enabling polymer surfaces with biocompatible and/or bioactive capabilities. Medical practitioners and pharmaceutical researchers have long relied on traditional polymers such as polyethylene for its proven effectiveness. Researchers at the University of Florida have developed a way to outfit such polymers with even greater utility, providing tremendous application potential. These materials offer the best of both worlds: the well-established strength and long-term stability of polyolefins, with the biological features of amino acids and peptides. The polymers "termed bio-olefins" may be engineered to be eithe non-reactive in the human body, or to beneficially react to surrounding tissue. New materials that could be derived from these bio-olefins would boost the effectiveness of existing medical devices, as well as lead to development of exciting new medical products.

Applications

Numerous biocompatible/bioactive materials for pharmaceutical and medical applications, including:

• coated stents
• bioresponsive membranes
• cell binding surfaces
• "bland" catheter materials
• coatings for existing medical devices

Advantages

• Peptide or amino acid attached to the polyolefin may be tailored to the bio-application itself, enabling enzymatic degradation
• Semicrystalline biocompatible polymer material may be used as a coating for medical implants, reducing the possibility of a rejection of the implanted device
• New bioactive polymer material may be used as a coating for medical implants, encouraging healing around the implanted device, or incorporation of the implanted material into existing tissue
• Surface of these polymer materials may be implanted with a drug, effectively treating the area surrounding the polymer

Technology

Amino acid and peptide entities are covalently attached as branches at exact locations along the polyolefin backbone resulting in a semicrystalline, biologically stable polymer. In addition, amino acid entities can be placed in the polyolefin backbone, resulting in a polymer capable of enzymatic degradation. The technology centers on amino acid and oligopeptide functionalities that are of potential interest for drug delivery systems and biomimetics. Synthetic macromolecular systems containing peptide and amino acid-based functionalities often resemble the naturally occurring parent structures with the advantages imparted by the incorporation of other functional groups through copolymerization or chemical modifications of their base structure.

*IP Issue Date

Feb 6, 2007

*IP Publication Date

Jul 24, 2003

*Principal Investigator

Name: Kenneth Wagener

Department:

Name: Fernando Gomez

Department:

Name: James Pawlow

Department:

Name: Timothy Hopkins

Department:

Country/Region

USA