AsiaIPEX is a one-stop-shop for players in the IP industry, facilitating IP trade and connection to the IP world. Whether you are a patent owner interested in selling your IP, or a manufacturer looking to buy technologies to upgrade your operation, you will find the portal a useful resource.

Back to search results

Biomaterials from Regenerated Silk Fibroin

Detailed Technology Description: Various novel methods for producing 3D porous biomaterials from regenerated silk fibroin (RSF) – which has wide ranging applications in tissue engineering, wound healing bandages, drug delivery, cosmetic applications etc.

*Abstract: TECHNOLOGY DESCRIPTION
NCL scientists have developed various processes for producing 3D porous biomaterials from regenerated silk fibroin (RSF). Our process for the accelerated gelation of RSF- resulting in a porous structure lowers the gelation time to a few hours instead of several days. The protein concentration can be between 0.1- 40%. It works in a broad pH range of 5 – 7.5,within temperatures ranging from 20-70˚C. Another process using electrospinning of RSF from an aqueous solution, forms 3D porous structures (like non-woven mats) which have various biomedical applications. Surface modification of such biomaterials for improved performance is currently under progress.

MARKET POTENTIAL
• The market for biomaterials such as RSF was predicted to be of $37.6 billion for 2011 and projected to reach $64.7 billion by 2015*^
• The global market potential for tissue engineering and regenerative medicines has been expected to exceed $118 billion by year 2013- mainly in the target potential areas of wound care and orthopaedics.**

* http://www.the-infoshop.com/report/mama179926-global-biomaterial.html - viewed 16/05/11 ^ http://www.the-infoshop.com/report/inde180852-glob-biomaterial.html-viewed 16/05/11 **http://www.medicalnewstoday.com/releases/141341.php- viewed 18/05/11

VALUE/ ADVANTAGES
• Free of microbial growth (superior performance of implants, lower toxicity)
• Shorter gelation time opens-up the potential spectrum of applications of the materials developed using this method
• Process is cheaper and faster (aqueous solution used instead of organic solvent- eliminates several intermediate steps)
• Implant that could be reproduced with great consistency and quality
• Wide range of pore sizes: 1-10 microns

APPLICATIONS
• In tissue engineering- as bio-degradable bio-absorbable scaffolds (due to lower inflammatory and superior mechanical properties) and damaged tissue regeneration (For ex. bone, nerves, ligament, etc)
• In wound healing bandages (provides a moist environment to facilitate re-epithiliazation, re-modeling of connective tissues and collagenization)
• As controlled drug delivery vehicles
• Silk fibroin peptides are used in cosmetics due to their glossy, flexible, elastic coating power, easy spreading and adhesion

TECHNOLOGY STATUS
• Demonstrated at the lab scale
• On the lookout for potential partners for licensing
• Patent application filed: PCT filed- PCT/IN2010/000506

CONTACT
Case Manager: Magesh N
Phone: +91-20-25902982
Email: m.nandagopal@ncl.res.in

Country/Region: USA

For more information, please click Here