Polymeric Systems for Signal Amplification
- Detailed Technology Description
- The platform technology enables polymeric nanostructures that are useful for high level signal amplification, particularly DNAThe systems of the invention comprise polymers and block copolymers, containing a dense arrangement of luminescent molecules that self-assemble into core-shell nanospheres. The polymeric nanospheres contain in the order of 200 polymer chains; each incorporates as many as 50 luminescent centers. When an analyte DNA associates with one polymeric nanosphere, it is effectively labeled with approximately 10,000 highly luminescent units.
- *Abstract
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Methods directed to increasing the sensitivity of gene detection typically rely on enzymatic amplification of the analyte (PCR). An alternative relies on systems designed to amplify the signal itself, instead of the target biomolecule. The methods of the invention are amenable to detection of DNA, RNA and proteins.
- Country/Region
- USA
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