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Joint injury repair via biomimetic tissue-tissue interface engineering

Summary: Soft tissue and joint injuries, such as rotator cuff injuries, are complex and often require surgical intervention. Current rotator cuff repair procedures that employ a synthetic tendon graft have a high failure rate due to poor biocompatibility and insufficient mechanical strength; therefore, a functional rotator cuff grafting system is in high demand. Furthermore, regeneration of the tendon-bone interface is critical for a comprehensive rotator cuff repair treatment. This technology is an implantable bio-scaffold for repairing rotator cuff injuries. The bio-scaffold promotes tissue repair by guiding cell attachment and matrix development within a physiologically appropriate structure.

Technology Benefits: Targets the tendon-bone interface, critical for treatment success and currently not regenerated during repairsOffers improved biocompatibility and mechanical strength over existing synthetic tendon graftsTreatment is applicable to both serious joint injuries and chronic joint degradation casesDesign can be applied beyond joint tissue regenerationPatent information:Patent Pending (US 20130280318) Tech Ventures Reference: IR 2852

Technology Application: Shoulder injuries, e.g. rotator cuff tearsChronic rotator cuff degeneration Knee injuries, e.g. injury to the anterior cruciate ligament (ACL)Other tissue-tissue interface regeneration treatments

Detailed Technology Description: None

*Abstract: None

*Inquiry: Satish RaoColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu

*IR: 2852

*Principal Investigator

*Publications: KL Moffat, ASP Kwei, JP Spalazzi, SP Doty, WN Levine, HH Lu. "Novel Nanofiber-Based Scaffold for Rotator Cuff Repair and Augmentation" Tissue Engineering Part A. 2009 Jan, 15(1):115-126.C Erisken, X Zhang, KL Moffat, WN Levine, HH Lu. "Scaffold Fiber Diameter Regulates Human Tendon Fibroblast Growth and Differentiation" Tissue Engineering Part A. 2013 Feb, 19(3-4):519-28.

Country/Region: USA

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