Transgenic mouse strain allows inducible genetic expression in kidney cells and nervous system
- Summary
- Frank Costantini, Ph.D.
- Technology Benefits
- Provides ability to induce genetic modification in the kidney or nervous system at any time in the mouse developmentTransgenic mice develop normally without disorders associated with disruptions in the endogenous geneProvides cellular modification in parts of the nervous system that previous mice lines may not allowPatent information:Patent PendingTech Ventures Reference: IR CU14313
- Technology Application
- Strain of transgenic mice to conduct experiments involving inducible cellular modifications in kidney cells and/or the nervous systemPotential enhancement of GDNF in the endogenous GDNF-producing cells for therapeutic research for Parkinson's diseaseFurther research into how low nephron numbers affect hypertension
- Detailed Technology Description
- Frank Costantini, Ph.D.
- *Abstract
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None
- *Inquiry
- Sara GusikColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu
- *IR
- CU14313
- *Principal Investigator
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- *Publications
- C. Cebrian, N. Asai, V. D'Agati, F. Costantini. The number of fetal nephron progenitor cells limits ureteric brancing and adult nephron endowment. Cell Reports, Vol. 7, Issue 1, Mar. 2014, pp. 127-137.Hantman AW, Jessell TM. Clarke's column neurons as the focus of a corticospinal corollary circuit. Nat Neurosci. 2010 Oct;13(10):1233-9. doi: 10.1038/nn.2637. Epub 2010 Sep 12
- Country/Region
- USA
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