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Focused ultrasound planning system enables blood-brain barrier opening with a single element transducer

Summary

Elisa E. Konofagou, Ph.D.

Technology Benefits

Minimally invasive due to transient creation of small BBB opening.Safe and quick relative to techniques such as cranial surgery.Non-toxic compared to drug-based methods for BBB disruption.Highly localized and cost-effective for access to specific regions of the brain.Enables single element transducer, MR guidance-free procedures.Patent information:Patent Pending (WO/2011/079177)Tech Ventures Reference: IR 2687

Technology Application

Recurrent drug delivery in Alzheimer’s, Parkinson’s and other central nervous system diseases.Localized delivery of toxic drugs to a tissue site of interest.Research tool for finely controlled membrane manipulation. High throughput drug screening in vivo.

Detailed Technology Description

Elisa E. Konofagou, Ph.D.

*Abstract

None

*Inquiry

Satish RaoColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu

*IR

2687

*Principal Investigator

*Publications

Y.S. Tung, F. Vlachos, J.J. Choi, T. Deffieux, K. Selert, E.E. Konofagou. In vivo transcranial cavitation threshold detection during ultrasound-induced blood-brain barrier opening in mice. Phys Med Biol, Vol. 55, Issue 20, Oct 2010, pp. 6141-55.T.Deffieux, E.E.Konofagou. Numerical study of a simple transcranial focused ultrasound system applied to blood-brain barrier opening. IEEE Trans Ultrason Ferroelectr Freq Control, Vol. 57, Issue 12, Dec 2010, pp.2637-53.B. Baseri, J.J. Choi, T. Deffieux, M. Samiotaki, Y, Tung, O, Olumolade, S.A. Small, B. Morrison, E.E.Konofagou. Activation of signaling pathways following localized delivery of systemically-administered neurotrophic factors across the blood-brain barrier using focused ultrasound andmicrobubbles. Phys Med Biol, Vol. 57, Issue 7, April 2012, pp. N65-N81.

*Web Links

WIPO: App. # PCT/US2010/061742

Country/Region

USA