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Allosterically-regulated protein hydrogel using leucine beta rolls

Summary: Scott A. Banta, Ph.D.

Technology Benefits: Can be easily deployed in the liquid state to cover or fill a variety of complex geometriesReversible state transition from a viscous liquid to a solid gel via allosteric regulationBiocompatible protein matrix compositionGel formation is induced simply by the addition of a readily-available and biocompatible element, calciumPatent information:Patent Issued (US 8,415,290)Patent Pending (US 20130237612)Tech Ventures Reference: IR CU12126

Technology Application: Biocompatible wound dressingsSustained-release drug delivery systemScaffolding in tissue engineeringCharge transfer and charge separation for biocatalytic electrodesBiosensing of ion concentrations (e.g. calcium)

Detailed Technology Description: Scott A. Banta, Ph.D.

*Abstract: None

*Inquiry: Satish RaoColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu

*IR: CU12126

*Principal Investigator

*Publications: K. Dooley, Y.H. Kim, H.D. Lu, R. Tu, S. Banta. Engineering of an environmentally responsive beta roll peptide for use as a calcium-dependent cross-linking domain for peptide hydrogel formation. Biomacromolecules, Vol. 13, Issue 6, Apr. 2012, pp. 1758-1764.S. Banta, I.R. Wheeldon, M. Blenner. Protein engineering in the development of functional hydrogels. Annual Review of Biomedical Engineering, Vol. 12, Aug. 2010, pp. 167-186.

Country/Region: USA

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