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Sensitive diagnostic test for the easy detection of the toxin causing bacterial vaginosis

Technology Benefits

-- Provides a more sensitive and easier to perform diagnostic test for bacterial vaginosis infection.-- Presents novel chimeric antibodies for the generation of new animal models of G. vaginalis colonization and bacterial vaginosis. -- Provides a novel polyclonal antibody for potential use in vaccination therapy to eliminate the problem of recurrent bacterial vaginosis infections currently seen using antibiotic treatmentsPatent information: ~ see link below ~ WO/2009/117373

Technology Application

-- Provides antibodies for the simple and sensitive detection of VLY, yielding a diagnostic tool for bacterial vaginosis infection.-- Polyclonal antibodies generated provide protection to VLY-infected cells, which can possibly lead to a vaccination therapy.-- The species non-specific chimera of VLY can be used to generate animal models of G. vaginalis infection-- Chimeric antibodies produced can be used to detect CD59-expressing cells, the human receptor recognized by VLY

Detailed Technology Description

Tech Ventures Reference: IR 2345; IR 2476Discovery of a toxin from Gardnerella vaginalis yields promise for a vaccine and animal models of bacterial vaginosis Bacterial vaginosis is a common yet difficult-to-treat vaginal infe...

*Abstract

None

*Inquiry

Sara GusikColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu

*IR

2345

*Principal Investigator

*Publications

-- Gelber, SE et al. "Functional and phylogenetic characterization of Vaginolysin, the human-specific cytolylsin from Gardnerella vaginalis," J Bacteriol, vol. 190, no. 11, pp. 3896-903, 2008.

*Web Links

WIPO: WO/2009/117373

Country/Region

USA