A novel method to inhibit growth of Varicella Zoster Virus
- Technology Benefits
- Provides a novel and effective method to control or inhibit infection/reactivation of the VZV virus for treating and preventing chicken pox and shinglesProvides an attractive alternative to the chicken pox vaccine (which has a poor rate of disease prevention) to alleviate the symptoms and lessen the severity of chicken pox/shinglesProvides a potential therapeutic method for other viral diseases such as outbreaks of HSV, which is highly homologous to VZV and shares a similar method of activation
- Technology Application
- Provides an antibiotic effective to inhibit replication of VZV in a host cellProvides an siRNA effective to inhibit VZV in a host cellProvides an assay to screen for candidates that inhibit VZV replication by quantitating the change in a chaperone protein activity Provides novel anti-viral mechanism for developing therapies against other viral infections such as HSV
- Detailed Technology Description
- This invention identified a novel anti-viral mechanism that is important for developing novel combination therapy, using VZV infection as an example. Infection and reactivation of VZV requires the transport of a viral protein ORF29p from the cytoplas...
- *Abstract
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None
- *Inquiry
- Peter GolikovColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu
- *IR
- 2246
- *Principal Investigator
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- *Publications
- Journal of Virology, July 2007, Vol. 81, No. 14, p7491-7503
- Country/Region
- USA
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