Combinatorial methods for inducing cancer cell death
- Summary
- Lead Inventors: Paul FisherA method for inhibiting proliferation and inducing cell death in a population of cancer cells by increasing the amount of the differentiation associated protein, mda-7 and decreasing RAS activity within the cell population is described.Nucleic acid molecules encoding mda-7 or anti-RAS antisense molecules are transferred into cancer cells using viral vectors. The anti-RAS agent can also be a ribozyme, a precursor of a triple helix, or a farnesyl transferase inhibitor. The method provides mda-7/anti-RAS combination therapy that is used to identify and treat suitable cancer cells, in particular, pancreatic cancer.
- Detailed Technology Description
- A method for inhibiting proliferation and inducing cell death in a population of cancer cells by increasing the amount of the differentiation associated protein, mda-7 and decreasing RAS activity within the cell population is described.Nucleic ...
- *Abstract
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None
- *Inquiry
- Peter Golikov Columbia Technology Ventures Tel: (212) 854-8444 Email: TechTransfer@columbia.edu
- *IR
- 1125
- *Principal Investigator
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- *Web Links
- Patent number: US20040191223
- Country/Region
- USA
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