P-Cadherin (12H6) Monoclonal Antibody
- Detailed Technology Description
- Project #: D1995-19bAntigen Specificity: P-Cadherin (Cadherin 3)Clone: 12H6Specificity: Reacts with ~120 KDa P-Cadherin proteinHost species: MouseReactive species: HumanDescription:The 12H6 monoclonal antibody reacts with human P-Cadherin. It is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy.Applications: Western blot, Immunofluorescence
- *Abstract
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- *Principal Investigator
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Name: Margaret Wheelock, Professor
Department: Biology
Name: James Wahl
Department: Department of Oral Biology
Name: Keith Johnson, Professor
Department: Oral Biology
- Country/Region
- USA
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