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Treatment of Pulmonary Disorders with Retinoic Acid or Other Retinoids by Inducing Formation of Gas-Exchange Units (Alveoli)

Detailed Technology Description: The present invention relates to the treatment of Emphysema by usingRetinoic acid, its esters and the analogues. These compounds, whenadministered, either bucally, sublingually or by nebulizer, result inenhancing alveolar function or development; and thus offer greattherapeutic and commercial potential in treating pulmonary diseasesinvolving alveolar dysfunction, such as emphysema.

*Abstract

*Publications: "Retinoic acid treatment abrogates elastase-induced pulmonary emphysema in rats," Massaro et al, Nature Medicine, vol. 3, No. 6,675-677 (1997). "Postnatal treatment with retinoic acid increases the number of pulmonary alveoli in rats," Massaro et al, Am. J. Physiol., 270, L305-L310 (1996).

*Stage of Development: Proof-of-concept demonstrated in mice.

Country/Region: USA

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