Hydrophilic Polymer Networks with Environmental Sensitivity (New NANI Formulations)
- Technology Benefits
- Eco-friendlyNo harsh solvent needBiocompatibleBiodegradable Cost No agent neededFasterproductionMaterial PropertiesMaximizesnumber of pH-responsive groupsAmenableto wider range of reagentsTolerantof waterNoshrinkage
- Detailed Technology Description
- NANI: A family of hydrogels that maybe tailored to provide continuous, multi-day stabilization ofnutrient and pH levels in a wide range of cell cultures and without the needfor manual intervention.
- *Abstract
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- *Background
- In vitro cell culturing is a common scientific techniqueused extensively worldwide. Successful cell culturing involves, in part,properly preparing and continually monitoring for proper temperature, pH, gasand nutrient content. Providing this optimal nutrient composition consistentlybecomes challenging during the weekends or holidays from the lab worker. The currently available delivery methods generally involves the use of polymers bearingalkaline amine functionalities, which can give rise to significant swelling andrapid release as the pH transitions from neutral to acidic conditions. Themajor problems identified with such responsive drug delivery systems includeslow response time, lack of mechanical strength, biocompatibility andbiodegradability.
- Country/Region
- USA
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