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Engineered Fibroblast Growth Factor for Enhanced Wound Healing

IP Title

Engineered FGF Compositions and Methods of Use Thereof

Detailed Technology Description

Fibroblast Growth Factor (FGF) is a naturally occurring substance in the body that has many roles.  One of them is to help heal wounds, FGF causes the wound to grow new blood vessels and new nerves.  Currently FGF is used commercially to help in the healing of wounds, however, the version of FGF now used for this purpose is quickly degraded by the presence near a wound of thrombin – which is a blood coagulant.A new type of engineered FGF has been invented that resists the degradation of thrombin, and has higher biological activity in the blood stream, thus leading to its being more effective in wound healing.  The new version of FGF has been shown to have twice the wound healing property of natural FGF.  Advantages of the new FGF are;1) Biologically extremely active2) Thrombin Resistant3) Thermo stable4) Economically viable5) Heparin independent mitogenic activity

Application Date

Mar 30, 2016

*Abstract

None

*Principal Investigator

Name: Suresh Kumar, Professor

Department:

Name: Rebecca Kerr

Department: Chemistry Biochemistry

Name: Srinivas Jayanthi

Department:

Name: David McNabb, faculty

Department:

Name: David Zaharoff

Department:

Name: Kartik Balachandran, Assistant Professor

Department: BMEG

Name: Bhanuprasanth Koppolu

Department:

Country/Region

USA