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Ratiometric Method for Non-linear Coherent Imaging

Technology Benefits

Functions with detector types suchas photodetector, photodiode, avalanche photodiode, photomultiplier tubeSingle frequency input light willproduce two or more optically mixed coherent signalsCan use any machine-readablemedium in implementationUtilize image contrast todistinguish between optically similar propertiesCan read atomic energy levels,molecular energy levels, and vibrational states of sampleApplicable to microscopy and imaging

Detailed Technology Description

Acoherent imaging system that is adapted for generating image contrast.

Countries

United States

Application No.

7,869,051

*Abstract

Theinvention includes a light source adapted to provide coherent light, resultingin optically mixed coherent signals and a detector adapted to receive the opticalsignals and produce an output signal in response. The output signal correspondsto any two frequencies of light in the optically mixed coherent signal. Illuminatinga sample with coherent light causes the sample to generate and receiveoptically mixed coherent signals. The system also includes a processorconnected to the detector and adapted to ratio the optically mixed coherentsignals in response. The detector receives photonic inputs emanated from the illuminatesample and produces an output signal.

*Background

Non-linear coherent imaging refers to imaging techniques inwhich multiple input photons are coherently combined to produce each outputphoton. In any optically non-linear medium, photons of all sum and differencefrequencies will be produced. Coherent Anti-Stokes Raman Spectroscopy (CARS) isthe process in which the vibrational state of a target molecule results in theresonant enhancement of photon generation. In general, the strength of anysignal produced at a given sum/difference frequency depends on the effect of molecularor atomic energy levels to resonant enhancement. The strengths of various sum/differencesignals depends on the detailed vibrational and electronic energy levels of themolecule being probed. In spite of the recent numerous enhancements inspectroscopy and microscopy, the aforementioned processes lack the ability togenerate image contrast. Given the inherent complexity in non-linear coherentimaging, it is desirable to provide image contrast in a manner that is bothcost-effective and easily reproducible. As such, there is a need for a coherentimaging system and/or method that is capable of generating image contrast in anefficient and effective manner.

*IP Issue Date

Jan 11, 2011

*IP Type

Utility

Country/Region

USA