Creation of RIPK3 Reporter and Conditional Deletion Mouse Model
- Detailed Technology Description
- This invention allows investigators to track endogenous RIPK3 expression in live cells and enables tissue-specific inactivation of RIPK3. Specifically, the last coding exon of the mouse RIPK3 gene is
- Countries
- Not Available
- Application No.
- None
- *Abstract
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This invention allows investigators to track endogenous RIPK3 expression in live cells and enables tissue-specific inactivation of RIPK3. Specifically, the last coding exon of the mouse RIPK3 gene is fused in-frame to the enhanced green fluorescent protein (GFP). LoxP sites flank the last coding exon of RIPK3. Crossing the RIPK3-GFP "floxed" mice to transgenic mice expressing Cre recombinase under the control of tissue-specific promoter enables conditional deletion and inactivation of RIPK3 in distinct tissues.
- *IP Issue Date
- None
- *IP Type
- Other Patent
- Country/Region
- USA
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