Dual Specific Binding Proteins Directed Against Immune Cell Receptors and Autoantigens
- Detailed Technology Description
- To address the need for improved multivalent binding proteins capable of binding immune cell receptors and autoantigens, this novel invention provides bispecific binding proteins that bind to two targ
- Countries
- Not Available
- Application No.
- None
- *Abstract
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To address the need for improved multivalent binding proteins capable of binding immune cell receptors and autoantigens, this novel invention provides bispecific binding proteins that bind to two targets: (1) a TLR-activating autoantigen and (2) an immune cell receptor (e.g., the B cell receptor) thereby forming an immune complex that is internalized and transported to TLRs resident in the endosomal compartment. The bispecific binding proteins are useful as a vehicle for the modulation of endosomal TLR signaling, and, hence, modulation of autoimmune disease.
- *IP Issue Date
- None
- *IP Type
- Other Patent
- Country/Region
- USA
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