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Genetically-induced obese mouse model for NASH and HCC

Detailed Technology Description: A mouse transgeinc line overexpressing Prohibitin in the liver and macrophages. This results in the spontaneous development of liver disease and liver cancer.

*Abstract: This technology provides the only animal model for the spontaneous development of fatty liver disease progressing to liver cancer. It is based on tissue specific overexpression of the mitochondrial regulatory molecule prohibitin. As such, the mouse embodies a novel therapeutic target for obesity, liver disease and cancer.

*Inquiry: Odd Bres,Ph.D.TechnologyManagerPh:+1(204)474.9407Cell: +1(204)292.4238Email: odd.bres@umanitoba.ca

Country/Region: USA

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