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Mouse obesity model: Mito-OB™ mouse
Detailed Technology Description
Dr. Mishra’s mouse model; Mito-OB ® has a specific alteration of prohibitin gene expression in white adipose tissue. Animals become obese and insulin resistant in a manner analogous to human obesity, diabetes and metabolic syndrome. Existing mouse obesity molecules are based on appetite dysregulation by the leptin system or un-defined characteristics of obesity-selected strains. For this reason the results of pharmacology and other therapeutic experiments on currently-available mouse obesity models may be misleading or even useless.
Country/Region
USA
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