Instrument to Enable use of Physiologically Relevant Human Clinical Linear Accelerator on Laboratory Mice
- Summary
- Researchers at Purdue University have developed a device that allows a mouse to undergo radiation treatment with a 6 MeV LINAC. The device consists of two major modules, a restraint system that acts as a head immobilizer and anesthetic delivery device for an individual mouse and a platform that secures five of the first modules in place for radiotherapy. This device also provides radiation bolus, a mass of material that modifies the dose of radiation and allows the mouse brain to be within the maximum energy deposition of the LINAC.
- Technology Benefits
- Immobilizes and delivers anesthetic to a mouse Facilitates use of the 6 MeV LINAC on mice
- Technology Application
- Radiotherapy studies
- Detailed Technology Description
- Carlos Perez-TorresPurdue Health Sciences
- Countries
- United States
- Application No.
- None
- *Abstract
-
- *Background
- The 6 MeV linear accelerator (LINAC) is a common device used in clinical radiotherapy for human patients with cancer. However, we do not have a full understanding of the effects of this treatment, so increased knowledge on the effects of this particular linear accelerator could help in the development of methods to inhibit the harmful effects of radiotherapy. Currently, due to its physical constraints, the 6 MeV LINAC is unable to be used on mice, preventing scientists from using this ubiquitous model animal to acquire a thorough understanding of how radiation from the 6 MeV LINAC causes effects including radiation-induced brain injury.
- *IP Issue Date
- None
- *IP Type
- Provisional
- *Stage of Development
- Prototype testing validated
- *Web Links
- Purdue Office of Technology CommercializationPurdueInnovation and EntrepreneurshipCarlos Perez-TorresPurdue Health Sciences
- Country/Region
- USA
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