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Direct Contact Blood Brain Barrier Triculture

Summary

Researchers at Purdue University have developed a model that represents a more restrictive, accurate model of the BBB. This model is a direct contact, triculture model containing astrocytes, pericytes, and the brain microvessel endothelial cells (BMEC) configured in a physiologically similar manner to an in vivo BBB. This method allows for direct contact between the pericytes and the astrocytes and measures the transendothelial electrical resistance (TEER) as an indirect measure of cell tightness. Researchers monitor the TEER until they determine a window in which a triculture would be of utility for permeability studies. This model will offer superior selectivity for screening neuroactive or neurotoxicant agents in vitro and help in the rational selection of candidates for advancement into further clinical studies based on its physiological similarity to the in vivo BBB cellular configuration. This model may also be adopted to select compounds that have a lower potential of eliciting a neurotoxicant effect.

Technology Benefits

More accurate model representing the BBB Allows materials to permeate through it Allows for direct contact between the astrocytes and pericytes

Technology Application

Medical/Health Pharmaceuticals Research & Development Drug discovery

Detailed Technology Description

Gregory KnippKnipp LabPurdue Industrial and Physical Pharmacy

Countries

United States

Application No.

None

Country/Region

USA

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