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Real Time Imaging Via Stimulated Raman Spectra Signal

Summary

Researchers at Purdue University have developed a multiplex stimulated Raman scattering (M-SRS) microscope that utilizes a parallel detection scheme to increase imaging speed from one second per pixel to twenty microseconds per pixel. This novel parallel detection device produces high-resolution images with a large signal to noise ratio that can be used to make quantitative measurements with a pixel dwell time of a few microseconds. The system has already been used to produce spectroscopic images of live pancreatic cancer cells that can be processed to parse out the location of lipids, proteins, and water in the cells. All this information will find application in histology, pharmacology, and clinical diagnosis.

Technology Benefits

Pixel dwell time of 20 microsecondsSpectral resolution of 5 1/cm covering 100x100 micrometers in less than 3 seconds

Technology Application

PharmaceuticalsMedical/HealthcareClinical DiagnosisCancer Detection

Detailed Technology Description

Ji-Xin ChengCheng LaboratoryPurdue Biomedical EngineeringPurdue Chemistry

Countries

United States

Application No.

9,068,949

Country/Region

USA

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