Discontinuous Atmospheric Pressure Interface
- Summary
- Purdue University Researchers have developed discontinuous atmospheric pressure ionization (DAPI), which is a method of interfacing atmospheric pressure ion sources, including electrospray and desorption electrospray ionization sources, to mass spectrometers, for example miniature mass spectrometers, in which the ionized sample is discontinuously introduced into the mass spectrometer. Discontinuous introduction improves the match between the pumping capacity of the instrument and the volume of atmospheric pressure gas that contains the ionized sample. The reduced duty cycle of sample introduction is offset by operation of the mass spectrometer under higher performance conditions and by ion accumulation at atmospheric pressure.
- Technology Benefits
- Allows for smaller mass spectrometers Increases portability and field use
- Technology Application
- Mass spectrometers Field use of mass spectrometers
- Detailed Technology Description
- R. Graham CooksPurdue Biomedical EngineeringAston Labs
- Countries
- United States
- Application No.
- 9,058,967
- *Abstract
-
- *Background
- Mass spectrometry (MS) is commonly used in analytical laboratories that study physical, chemical, or biological properties of compounds. MS uses large vacuums to lower pressure in the chambers, which is necessary to maintain the integrity of the sample. The large vacuums limit the flexibility of adapting MS for portability and field use.
- *IP Issue Date
- Jun 16, 2015
- *IP Type
- Continuation
- *Stage of Development
- Prototype testing validated
- *Web Links
- Purdue Office of Technology CommercializationPurdueInnovation and EntrepreneurshipR. Graham CooksPurdue Biomedical EngineeringAston Labs
- Country/Region
- USA
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