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Dithiocarbamate Ligands with Biosensing Applications

Summary

Purdue University researchers have developed an innovative method for coating metal surfaces with dithiocarbamate (DTC) ligands. DTC ligands can absorb onto metal surfaces with the same degree of generality as thiols, but with greater resistance to surface desorption or displacement. DTC ligands can be formed under extremely mild conditions and are especially useful for robust functionalization of metal substrates and nanoparticles intended for biological labeling and biosensing applications.

Technology Benefits

Can withstand a wide range of environments including a pH range of 1 to 12Resistant to displacement by competing surfactants Increased stability under physiological conditions

Technology Application

Biological LabelingBiosensing

Detailed Technology Description

Alexander WeiWei Research GroupPurdue Chemistry

Countries

United States

Application No.

7,803,568

*Abstract

*Background

The functionalization of metal substrates with organic ligands has become a standard practice in surface science and nanomaterials chemistry. Molecular monolayers are often formed spontaneously by a simple chemisorption process. The self-assembly of alkanethiols on gold is a method for preparing surfaces with tunable physical or chemical properties or with biological recognition elements. While such self-assembled monolayers (SAMs) have proven to be very useful, they are also limited by their chemical stability. Thiols can be readily oxidized to disulfides, sulfinates, or sulfonates and desorb or be displaced from the surface by other molecules. Alkanethiol-based SAMs have been shown to lack the long-term stability necessary for most biomedical applications.

*IP Issue Date

Sep 28, 2010

*IP Type

Utility

*Stage of Development

Proof of Concept

*Web Links

Purdue Office of Technology CommercializationPurdueInnovation and EntrepreneurshipAlexander WeiWei Research GroupPurdue Chemistry

Country/Region

USA