Antibody for Tubulointerstitial Nephritis Antigen
- Technology Benefits
- Easy to produceSpecies-specific
- Detailed Technology Description
- Identification of species-specific epitopes for generating antibodies against tubulointerstitial nephritis antigen (TINag) #researchtool #antibody #therapeutics
- *Abstract
-
Northwestern researchers have developed a method for production of species-specific tubulointerstitial antigen (TINag) antibodies. Tubulointerstitial kidney disorders are known to develop due to the presence of TINag, which stimulates production of auto-reactive antibodies. If TINag antibodies are produced, the disease progresses rapidly, leading to kidney failure. Therefore, study of TINag and TINag specific antibodies is a crucial step to understanding severe kidney disease and discovering therapies against it. Until the development of this innovative method by Prof. Kanwar and colleagues, TINag antibody production was a cumbersome and labor-intensive process. This TINag antibody production method could accelerate the pace of kidney disease research enabling development of therapeutics in the future.
- *Inventors
- Yashpal Kanwar* Ping Xie
- Country/Region
- USA
