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Scar-Free Tissue Regeneration

Technology Benefits
Scar-lessregeneration of tissueAny tissue canbe regenerated
Detailed Technology Description
Polymer-based drug delivery system that activates scar-free tissue regeneration #therapeutics #drugdelivery #biomedical #wound healing #materials #polymer

A recent discovery identified hypoxia-induced factor (HIF) as a key mediator of epimorphic tissue regeneration. This kind of regenerative process has been made famous by salamanders, a species that can re-grow whole limbs through this process. In humans, this kind of tissue generation has never been successfully recapitulated. Armed with the knowledge that HIF activation can promote this process, scientists have been able to induce epimorphic regeneration in human tissues by using a hydrogel-like polymer to deliver HIF-activating drugs directly into affected areas. Once inside the targeted tissue, the loaded hydrogel polymer is capable of releasing the drug over several days, stimulating HIF in a continuous manner. Importantly, this novel approach can be applied to any type of human tissue, granting it many applications in clinical medicine. 

Iossif A StrehinPhillip B MessersmithEllen Heber-Katz
Wilson EK (2015) Small Molecule Triggers Tissue Renewal, C&EN Chemical and Engineering News, 39: 7. Zhang Y, Strehin I, Bedelbaeva K, Gourevitch D, Clark L, Leferovich J, Messersmith PB, Heber-Katz E (2015) Drug-induced Regeneration in Adult Mice, Science Translational Medicine, DOI: 10.1126/scitranslmed.3010228.

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