Reagent for Attaching Biomolecules to Surfaces
- Technology Benefits
- Modification of oligonucleotides at the 3’ and 5’ endsWide range of biomolecules can be modified – oligonucleotides, polypeptides, lipids and carbohydratesWide range of surfaces can be modifiedLow cost to manufacture
- Detailed Technology Description
- This invention providesa novel reagent for use in oligonucleotide and related structures, and methodsfor modifying a wide range of biomolecules in order to attach them to diversetypes of surfaces.#researchtool #reagent #materials #biomedical
- *Abstract
-
The invention describes a novel non-nucleoside tosyl phosphoramidite formodification of biomolecules, like oligonucleotides, from both the 3’ and 5’ends. The phosphoramidite is prepared conveniently from commercially availablestarting materials and can be applied to modify molecules post-synthesis orduring the synthesis of oligonucleotides to prepare tosylated oligos bearing asingle or multiples of tosyl functionalities. The tosyl-modified biomoleculescan then be attached on modified surfaces like gold, glass, polymer, metal andplastic.
- *Inventors
- Robert ElghanianChad A. Mirkin
- Country/Region
- USA
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