PPAR-delta agonists and high fat diet as enhancers of intestinal progenitor function
- Detailed Technology Description
- None
- *Abstract
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Whitehead Intellectual Property Office is seeking a licensee for intellectual property that shows high-fat diet (HFD)-induced obesity enhances the amount and function of intestinal stem cells (ISCs) in the mammalian intestine. Although important epidemiological and rodent studies link obesity to colon cancer incidence, little is known about how exactly these cells adapt to pro-obesity diets in order to increase the potential of cancer onset and tumor development. Whitehead researchers have determined that a HFD may raise cancer risk by increasing stem-cell divisions, which are the implicated cell-of-origin for many tumors and therefore cancers.
- Country/Region
- USA
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