A Device for Sensing, Enumerating and Imaging Rare Cells with Diffuse Light (Tomographic In Vivo Flow Cytometer)
- Technology Benefits
- The device/system:ΓÇóEnables faster and efficient samplingΓÇóIs a tomographic in vivo flow cytometer, comprising a unique combination of a diffuse light and a high-sensitivity photon counting approachΓÇóIs associated with 200 to 500 times improved sensitivity as compared to prior-art approachesΓÇóEnables sensing of cells travelling through much larger blood vessels as compared to conventional systemsΓÇóAllows for a higher flow rate (0.2mL ΓÇô 0.5mL per minute) as compared to conventional approachesΓÇóWould be commercially useful in the studying of cancer metastatic spread and stem cell trafficking, along with developing novel therapeutic compounds
- Detailed Technology Description
- None
- *Abstract
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Currently, in vivo flow cytometry is one of the most common procedures used for the detection, sensing and counting of circulating cells. However, this technique is associated with possible limitations such as interrogation of only small blood vessels and blood volumes (~1 micro-liter of blood per minute), the potential escape of rare circulating cells (such as hematopoietic stem cells), and low sensitivity (with the lowest detection limit of about 10,000 cells). This invention discloses a novel device/system useful for effectively detecting, counting and imaging rare circulating cells in the blood stream non-invasively.
- *Principal Investigator
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Name: Charles Lin
Department:
Name: Mark Niedre
Department:
Name: Eric Zttergren
Department:
- Country/Region
- USA
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