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Compositions and Methods for Measurement of Analytes

Technology Benefits

The microworm sensor:ΓÇóIs a tube-like structure with an extremely compact sizeΓÇóAllows for a semi-invasive measurement of in vivo concentration of analytesΓÇóIs capable of encapsulating sensing components and thereby enables in-vivo sensingΓÇóHas a coating made up of biocompatible and/or biodegradable materialΓÇóSuccessfully limits the immune response mediated by macrophage activationΓÇóAllows for an encapsulation of commonly used fluorescent assays in a small space and their further implantation into the skinΓÇóWould be commercially useful as an in vivo fluorescent sensor for the detection of biological analytes such as sodium, glucose, histamine, etc.

Detailed Technology Description

None

*Abstract

Currently, many approaches are used for the detection of analytes present in biological, environmental and chemical samples. However, most of these approaches only measure analytes in vitro or ex vivo. For example, in the case of biological samples, analytes are measured in blood withdrawals through the use of external analyte specific sensors or detection assays such as ELISA. Moreover, these external sensors are not suitable for in-vivo detection of analytes as they are usually incompatible with the in vivo environment. The proposed approach enables the development and use of novel microworm sensors for detection of analytes and other small molecules using fluorescence measurements through the skin.

*Principal Investigator

Name: Kevin Cash

Department:

Name: Heather Clark

Department:

Name: John Dubach

Department:

Name: Karen Gleason

Department:

Name: Gozde Ozaydin-Ince

Department:

Country/Region

USA