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Detecting Heparin Induced Thrombocytopenia

Technology Benefits

Improved stability of the targets complexes and better preservation oftarget epitopes.

Technology Application

Diagnosing heparin-induced thrombocytopenia.

Detailed Technology Description

Heparin induced thromocytopenia (HIT) and thrombosis is aserious side effect of heparin therapy cause by antibodies thatrecognize complexes consisting of heparin and platelet factor four(PF4), a platelet alpha granule protein. These patents coverdetection of HIT antibodies using1) complexes made up of PF4 and polyvinyl sulfonate (a linear polyanion) and2) PF4 complexed with heparin immobilized linked covalently at its reducing end to a solid phase.Exclusively licensed worldwide. Partnership opportunities will beforwarded to our exclusive licensee. US Patents 5,972,718 and5,972,717. Foreign country applications currently in prosecution.Heparin is given to millions of patients annually. About 5% are at risk forHIT. Any patient receiving heparin who develops unexplainedthrombocytopenia should be tested for antibody.

*Abstract

Heparin induced thromocytopenia (HIT) and thrombosis is aserious side effect of heparin therapy cause by antibodies thatrecognize complexes consisting of heparin and platelet factor four(PF4), a platelet alpha granule protein.

*Principal Investigator

Name: Benjamin Boldt

Department:

Name: Gian Visentin

Department:

Name: Manouchehr Moghaddam

Department:

Name: Richard Aster

Department:

Country/Region

USA