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Mouse anti-bat monoclonal antibody

Technology Benefits

HostMouseTarget SpeciesBat (microchiropteran only)Targeted ApplicationsELISA, SDS-PAGE, Western blot, Immunohistochemistry and immunofluorescenceCloneBT1-4F10AdvantagesDiagnosis of rabies in bats vs. typical measurement by viral neutralization assaysEnable research on fundamental properties of the microchiropteran immune systemAssess the status of bat immunity to specific pathogens i.e. Geomyces destructans, the etiologic agent of white nose syndromeProvide diagnostic assays for analyses of antibodies from bat seraProvide a platform for analysis of bat tissues by ELISA, immunochemistry, immunohistochemistry, Western blot and flow cytometry

Technology Application

ELISA, SDS-PAGE, Western blot, Immunohistochemistry and immunofluorescence

Detailed Technology Description

One of the problems with studying bat immunology is that no serologic assay exists to probe bat responses to various pathogens such as rabies, severe acute respiratory syndrome (SARS) and Geomyces destructans, the etiologic agent of white nose syndrome, a condition associated with an unprecedented bat mortality event in the United States. Filling that gap was ideal for our organization since our rabies lab receives bats for testing throughout the year. So far, experimentation with our unique mAb (BT1-4F10) showed that it could distinguish between rabies infected versus non-infected bats in an assay commonly used to detect rabies but never before in bats.

Supplementary Information

Inventor: John Malcolm Nicholls | Kwokyung Yuen | Joseph Sriyal Malik Peiris | Frederick C. Leung | Yi Guan | Litman Poon | Kwokhung Chan
Priority Number: CN1768140B
IPC Current: C12N001550 | A61K0039215 | A61P001100 | A61P003114 | C07K0014165 | G01N0033569
Assignee Applicant: Univ Hongkong Versitech City Ltd
Title: A high-troughput diagnostic assay for the human virus causing severe acute respiratory syndrome (SARS) | High flux diagnostic test to the human virus causing severe acute respiratory syndrome (SARS)
Usefulness: A high-troughput diagnostic assay for the human virus causing severe acute respiratory syndrome (SARS) | High flux diagnostic test to the human virus causing severe acute respiratory syndrome (SARS)
Summary: The nucleic acid molecule and polypeptide, methods, and kit are useful diagnosing and monitoring the spread of SARS. The vaccine and pharmaceutical compositions are useful for treating SARS.
Novelty: New nucleic acid molecule encoding nucleocapsid- or spike-gene protein of a human Severe Acute Respiratory Syndrome (hSARS) virus, useful for diagnosing and treating SARS

Industry

Biomedical

Sub Category

Pathogen

*Abstract

Emerging pathogens, many of them viruses, continue to surprise us by an underappreciated source, bats. Although bats are among the most abundant, diverse and geographically dispered orders of terrestrial mammals, typically little has been studied about the bat as a host carrying microorganisms and transmitting pathogens to other species. In fact, bats are increasingly proving to be rich reservoirs of emerging viruses and re-emerging viruses as we disrupt by encroaching natural areas exposing not only ourselves, but our domesticated animals to viruses that earlier lacked opportunities to jump species.

Country/Region

USA