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Standard surface electrocardiogram (EKG) reconstruction from implanted device electrograms (EGM)

Detailed Technology Description

None

*Abstract

This invention is a method of reconstruction of the standard 12-lead surface EKG given values of the electrical potential from an implanted medical device. This implanted device can be oriented in an arbitrary fashion and reconstruction technique is obtained through physical measurement of the orientation of the implanted device or correlation with a standard 12-lead EKG obtained from the patient.The transformation of the EGM to the EKG will then be determined for the individual patient. This transformation will encompass the information about lead electrodes and can positions as well as about the geometry of the chest for that individual patient and the way the heart is sitting in the chest. Given the changes in the way the heart sits in the chest with different positions, a different transformation can be obtained for the multiple positions including but not limited to the supine, prone, standing, sitting and decubitus positions.Applications:1) Ischemia detection2) Myocardial Infarction detection3) Electrolyte abnormalities detection4) Assessment of effect of medications 5) Improved rhythm discriminationAdvantages:1) Currently there is no implantable device that is being used to detect ischemia, myocardial infarction, electrolyte imbalances, or drug effects on the heart such as QT prolongation.Stage of Development:1) Animal studies using pigs have shown that 12-lead EKG can be reconstructed and that these reconstructed EKG's were similar to the recorded ones and could identify ischemia reliably.2) Currently enrolling patients in the EKG reconstruction (human) protocolProvisional patent application filed

*Principal Investigator

Name: George Mendenhall, Cardiology Fellow

Department: Med-Medicine

Name: Samir Saba, Assistant Professor

Department: Med-Medicine

Name: Jeffrey Williams, Fellow in Cardiovascular Disease

Department: UPMC Cardiovascular Institute

Country/Region

USA