PINCH-2 recombinant protein
- Detailed Technology Description
- None
- *Abstract
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The inventors have cloned a novel human protein (termed as PINCH-2) that forms a complex with integrin-linked kinase (ILK), an oncogenic protein. They have mapped the ILK-binding site to the first LIM (LIM1) domain of PINCH-2. PINCH-2 localizes to cell-extracellular matrix contact sites as well as the nucleus. The interaction with ILK is required for the localization of PINCH-2 to cell-ECM contact. Importantly, PINCH-2 regulates the interaction between PINCH-1 and ILK. Overexpression of PINCH-2 significantly reduced cell shape change and motility. Thus, PINCH-2 is an important regulator of ILK and PINCH-1 functions and a valuable target in the therapeutic control of human diseases involving cell-extracellular matrix adhesion, migration and signal transduction.Application1) PINCH-2 and its derivatives could be used to regulate ILK functions.Available for licensing
- *Principal Investigator
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Name: Chuanyue Wu, Associate Professor
Department: Med-Pathology
- Country/Region
- USA
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