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TM4 Conditional Shuttle Plasmids and Uses Thereof

Detailed Technology Description
None
*Abstract
The present invention provides a conditional shuttle phasmid constructed by inserting a cosmid into a non-essential region of the TM4 mycobacteriophage that introduces DNA of interest into mycobacteria, especially M. tuberculosis complex organisms and other slow growing mycobacteria. The present invention provides a recombinant mycobacterium which expresses a DNA of interest incorporated into its chromosome by a TM4 conditional shuttle phasmid containing the DNA of interest. The present invention further provides a mycobacterial auxotrophic mutant and a method of generating auxotrophic mutants.
*Principal Investigator

Name: Stoyan Bardarov

Department:


Name: Graham Hatfull

Department: Distinguished Faculty-Dietrich School of Arts and Sciences


Name: William Jacobs, Jr, Investigator and Professor

Department: Department of Microbiology and Immunology
Country/Region
USA

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