Genetic Method to Identify Persons at Greater or Lesser Cardiovascular Disease Risk
- Detailed Technology Description
- None
- *Abstract
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The present invention relates to identifying an ACE genotype which correlate with improved success in sodium excretion in hypertensive individuals engaged in exercise training. The inventors have discovered that the angiotensin converting enzyme (ACE) gene serves as a genetic marker which positively correlates with improved success in increasing sodium excretion levels in hypertensive individuals. Specifically, the inventors have found that those individuals possessing the "II" ACE genotype increased their sodium excretion levels significantly more than those individuals possessing either the "ID" or "DD" ACE genotype. The present invention is directed to a method of increasing sodium excretion levels in a hypertensive subject, comprising: identifying a hypertensive subject having an II genotype for an angiotensin converting enzyme gene; and engaging the subject in limited exercise training for a period of time sufficient to increase the subject's sodium excretion levels.
- *Principal Investigator
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Name: Michael Brown
Department:
Name: Robert Ferrell, Professor
Department: All Temps
Name: James Hagberg
Department:
- Country/Region
- USA
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