Phosphatase Inhibitors
- Detailed Technology Description
- None
- *Abstract
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The regulation of protein phosphorylation by kinases and phosphatases controls many eukaryotic cell functions, including signal transduction, cell adhesion, gene transcription and cell proliferation. The identification and characterization of kinases, phosphatases, and inhibitors thereof thus allows pharmaceutical regulation of a variety of cellular functions. The present invention provides inhibitors of protein phosphatases, and methods of making and using the inhibitors. The compounds of the present invention are useful, for example, as inhibitors of cell proliferation.
- *Principal Investigator
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Name: April Cunningham
Department:
Name: John Lazo, Professor Emeritus
Department: Departments of Pharmacology & Chemistry
Name: Robert Rice
Department:
Name: Peter Wipf, Professor
Department: Chemistry
- Country/Region
- USA
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