Prognostic Test for Alzheimer's Disease
- Detailed Technology Description
- None
- *Abstract
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The invention is directed to a method for screening for the risk of developing Alzheimer's disease (AD) in a subject by detecting the presence or absence of the APOE4 allele and the presence or absence of the ACT alleles which modify the risk of AD associated with the APOE4 allele. The invention offers a non-invasive method to identify individuals at high risk for the development of AD. Individuals for which the diagnostic methods of the present invention may have particular relevance include those with a family history of AD, individuals with cognitive decline, elderly individuals, and all others whose history or symptomology suggest an inquiry into a diagnosis of AD or assessment of risk. Biological samples which can serve as a source for the analysis of nucleic acid or protein for detection of both ACT and APOE polymorphisms include blood, cerebrospinal fluid (CSF) and tissue culture samples.
- *Principal Investigator
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Name: Steven DeKosky, Chair, Department of Neurology
Department: Med-Neurology
Name: Mohammad Kamboh
Department: GSPH-Human Genetics
- Country/Region
- USA
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