Method of obtaining immunogenic peptides from cells expressing temperature-sensitive mutants of major histocompatibility complex molecules
- Detailed Technology Description
- None
- *Abstract
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The present invention relates generally to the biosynthesis of temperature-sensitive major histocompatibility complex ("MHC") molecules, and more particularly relates to temperature-sensitive mutants of heavy chains of MHC class I molecules. According to the invention certain, preferably, immunogenic peptides that are expressed at the cell surface of viable cells that harbor genes for the temperature-sensitive mutants may be released under certain conditions. Peptides so obtained may find use in the development of viral or tumor vaccines, or alternatively as a means to treat autoimmune diseases.
- *Principal Investigator
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Name: Russell Salter, Associate Professor
Department: Med-Immunology
- Country/Region
- USA
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