Recombinant Luciferase Mycobacteriophages for Rapid Diagnosis of Tuberculosis
- Detailed Technology Description
- None
- *Abstract
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This invention relates to mycobacterial species-specific reporter mycobacteriophages (reporter mycobacteriophages), methods of producing said reporter mycobacteriophages and the use of said reporter mycobacteriophages for the rapid diagnosis of mycobacterial infection and the assessment of drug susceptibilities of mycobacterial strains in clinical samples. In particular, this invention is directed to the production and use of luciferase reporter mycobacteriophages to diagnose tuberculosis. The mycobacterial species-specific reporter mycobacteriophages comprise mycobacterial species-specific mycobacteriophages which contain reporter genes and transcriptional promoters therein. When the reporter mycobacteriophages are incubated with clinical samples which may contain the mycobacteria of interest, the gene product of the reporter genes will be expressed if the sample contains the mycobacteria of interest, thereby diagnosing mycobacterial infection.
- *Principal Investigator
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Name: Barry Bloom
Department:
Name: Graham Hatfull
Department: Distinguished Faculty-Dietrich School of Arts and Sciences
Name: William Jacobs, Jr, Investigator and Professor
Department: Department of Microbiology and Immunology
- Country/Region
- USA
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