Regulation of Maturation of Antigen-Presenting Cells Using Microenvironmental Factors (Extracellular Matrix Proteins)
- Detailed Technology Description
- None
- *Abstract
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A novel transplantation method for enhancing tolerogenicity in a host mammal to a transplant graft specimen from a donor mammal is disclosed. According to this method, immature mammalian dendritic cells propagated in the presence of a cytokine are administered to the host mammal in advance of transplantation. Tolerogenicity is enhanced in the host mammal when the immature mammalian dendritic cells concentrate in T-dependent regions of secondary lymphoid tissue of the host mammal, where the expression of major histocompatibility complex class II antigen by the immature mammalian dendritic cells is upregulated. Also disclosed is a novel method of effecting the maturation of immature dendritic cells in the presence of a cytokine and an extracellular matrix protein. These mature mammalian dendritic cells, which upregulate the expression of major histocompatibility complex class II antigen, can then be used to enhance the immune response of a host mammal.
- *Principal Investigator
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Name: Anthony Demetris
Department: Med-Pathology
Name: Thomas Starzl
Department: Med-Surgery
Name: Angus Thomson, Professor of Surgery and Mol. Gen. & Bio
Department: Med-Surgery
- Country/Region
- USA
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